Neurotransmitters-mediated ATP release from smooth muscles
نویسندگان
چکیده
منابع مشابه
Release of neurotransmitters from glia.
There is no question about the fact that astrocytes and other glial cells release neurotransmitters that activate receptors on neurons, glia and vascular cells, and that calcium is an important second messenger regulating the release. This occurs in cell culture, tissue slice and in vivo. Negative results from informative experiments designed to test the mechanism of calcium-dependent neurotran...
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The synapse is the point of functional contact between one neuron and another. It is the primary place at which information is transmitted from neuron to neuron in the central nervous system or from neuron to target (gland or muscle) in the periphery. The simplest way for one cell to inform another of its activity is by direct electrical interaction, in which the current generated extracellular...
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1. The present study was addressed to clarify the subtypes of P2-purinoceptor involved in ATP release and contraction evoked by alpha, beta-methylene ATP (alpha, beta-mATP) and other P2-agonists in guinea-pig ileum. 2. alpha, beta-mATP 100 microM produced a transient and steep contraction followed by ATP release from tissue segments. These maximum responses appeared with different time-courses ...
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8 9 10 11 12 D. MacMillan*, C. Kennedy & J.G. McCarron 13 14 15 Strathclyde Institute of Pharmacy and Biomedical Sciences, 16 University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, UK 17 18 19 20 21
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Results. In general, CNP and SNP exerted differential inhibitoiy effects on muscarinic-receptorinduced responses in CM and Sph isolated from the various species. Thus in bovine CM, SNP stimulated cGMP formation in a timeand concenu^ation-dependent manner and dose dependently inhibited CCh-induced IP3 production and contraction. These effects were inhibited by LY 83583, a soluble guanylyl cyclas...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1990
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)32919-1